Arapahoe County · Colorado
2 listed clinics in Littleton. Confirm treatment options and current availability directly with each practice.
Independent directory · confirm services and addresses directly. Educational information, not medical advice.
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Littleton is a prominent community primarily located in Arapahoe County, situated in the southern portion of the Denver metropolitan area along the Colorado Front Range. Known for its historic downtown, the South Platte River corridor, and access to numerous regional parks, Littleton provides a suburban environment with seamless ties to the broader medical infrastructure of the Denver metro region. Residents exploring specialized mental health care, including ketamine and Spravato therapy, benefit from a well-connected network of healthcare facilities across this urban corridor.
When considering advanced depression treatments, residents can review several regional clinic offices as comparisons. For example, nearby in Englewood, Rocky Mountain Mind and Body - integrative psychiatric practice and Ketamine Infusion Therapy offers ketamine infusion therapy. Just south in Lone Tree, Rose NeuroSpa describes providing Spravato treatment. For those looking toward central Denver, Relief Mental Health lists both IV ketamine and Spravato, and Denver Ketamine Clinic offers Spravato and ketamine therapy.
Navigating healthcare options along the Front Range allows patients to find a facility that aligns with their clinical needs. To learn more about care options in other Colorado communities, you can view our informational guides for Lakewood, Boulder, and Erie. Evaluating these facilities thoroughly ensures patients understand the necessary protocols before starting any new therapy.
5808 South Rapp Street, Suite 100, Littleton
4.8(263 Google reviews)
Balanced Mental Wellness - Psychiatry & Ketamine is listed in Littleton, Colorado. The listed appointment address is 5808 S Rapp St Ste 100, Littleton, CO 80120, USA. Confirm the current location with the practice before travelling.
26 West Dry Creek Circle, Suite 200, Littleton
4.7(42 Google reviews)
Vitalitas Denver Ketamine Infusion Center is listed in Littleton, Colorado. The listed appointment address is 26 W Dry Creek Cir Suite 200, Littleton, CO 80120, USA. Confirm the current location with the practice before travelling.
Treatment schedules vary by clinic and treatment type, so plan transportation for each visit. Distances below are straight-line miles from Littleton.
2.9 miles away · Englewood
750 West Hampden Avenue, 215, Englewood
4.6(70 Google reviews)
Treatment information
5.9 miles away · Centennial
6075 South Quebec Street, Centennial
4.7(116 Google reviews)
Ballen Medical & Wellness - Ketamine Therapy in Denver is listed in Centennial, Colorado. The listed appointment address is 6075 S Quebec St, Centennial, CO 80111, USA. Confirm the current location with the practice before travelling.
6.3 miles away · Centennial
7600 East Arapahoe Road, 106, Centennial
5.0(1 Google reviews)
Sage Rose Health- Ketamine Therapy in Centennial, CO is listed in Centennial, Colorado. The listed appointment address is 7600 E Arapahoe Rd 106, Centennial, CO 80112, USA. Confirm the current location with the practice before travelling.
6.5 miles away · Denver
7900 East Union Avenue, 1100, Denver
Ketamine Treatment Denver is listed in Denver, Colorado. The listed appointment address is 7900 E Union Ave 1100, Denver, CO 80237, USA. Confirm the current location with the practice before travelling.
6.5 miles away · Denver
2755 South Locust Street, 116, Denver
4.5(22 Google reviews)
Summit Ketamine Innovations is listed in Denver, Colorado. The listed appointment address is 2755 S Locust St 116, Denver, CO 80222, USA. Confirm the current location with the practice before travelling.
6.9 miles away · Highlands Ranch
8671 South Quebec Street, 240, Highlands Ranch
5.0(90 Google reviews)
Treatment information
Patients in Littleton researching ketamine therapies will find two distinct financial pathways depending on the specific treatment. Off-label ketamine, which includes intravenous (IV), intramuscular (IM), and sublingual forms, is largely a self-pay service. Since these applications are not FDA-approved for psychiatric use, insurance rarely covers them. Patients should ask clinics for a detailed, written estimate covering the initial assessment, the required series of induction sessions, and future maintenance visits. The FDA warns patients and health care providers about potential risks associated with compounded ketamine products, noting the importance of informed decision-making.
Conversely, Spravato is an FDA-approved esketamine nasal spray for specific adult depression indications. Because it is an approved treatment, Spravato may be covered by major health insurance plans, though prior authorization is frequently required. Coverage varies significantly between policies, so patients should confirm their benefits directly with their insurer. Additionally, patients should factor in the cost of travel to clinics for repeated visits, as well as the time required for post-treatment observation. Even for residents staying within the Denver metro area, commuting during high-traffic periods should be considered when estimating the total time and resources required for care.
Successfully managing a ketamine or Spravato treatment regimen requires a thorough plan assessment, a commitment to repeated visits, and structured follow-up. For Littleton residents commuting within the Front Range, traffic conditions and distances to surrounding cities like Denver or Englewood can affect travel times for these time-intensive appointments. While telehealth may support initial psychiatric assessments and routine check-ins, it does not establish home treatment availability.
Safety protocols for Spravato mandate that the medication is administered exclusively in a certified healthcare setting. After administration, patients undergo at least two hours of careful clinical observation. You are not allowed to drive until the next day after a restful sleep, meaning a responsible adult must be available for pickup after every appointment. Spravato is never administered at home. Other compounded ketamine formulations are prescribed off-label by some clinicians for home use; however, these are not FDA-approved for psychiatric care, and the FDA warns about the risks of use without on-site monitoring.
For those in distress, support is available 24/7. Contact the 988 Colorado Mental Health Line by dialing 988. In cases of medical emergencies, dial 911.
Compounded ketamine formulations, such as IV, IM, and sublingual methods, are used off-label for psychiatric conditions and are not FDA-approved. Spravato, an esketamine nasal spray, is the only formulation FDA-approved specifically for certain adult depression indications when it is administered in a certified clinic.
Off-label ketamine therapies are typically self-pay, as health insurance rarely covers them for mental health purposes. Spravato, however, is an FDA-approved medication and may be eligible for insurance coverage. This depends entirely on your specific policy, and the clinic will typically need to obtain prior authorization.
No, you cannot drive yourself or take a rideshare unaccompanied. Clinical safety protocols require a responsible adult to provide your transportation home after the mandatory two-hour observation period. Driving is strictly prohibited until the day following your treatment, after you have had a restful sleep.
You should expect to spend over two hours at the clinic for each appointment. After the medication is carefully administered, there is a mandatory clinical observation period of at least two hours to monitor for any side effects before the staff allows you to be discharged.
Spravato is never administered at home. Some clinicians prescribe compounded off-label ketamine for home use, but these specific formulations are not FDA-approved for psychiatric conditions. The FDA strongly warns against using compounded ketamine without professional on-site monitoring due to potential adverse reactions and safety risks.
Immediate support is available at any time. You can call or text the 988 Colorado Mental Health Line at [988](tel:988) for confidential help and crisis intervention. If you or someone else is experiencing a severe medical emergency, please dial [911](tel:911) right away for emergency responders.
Costs, coverage & aftercare
IV, IM and compounded ketamine for psychiatric conditions are off-label; many programs are self-pay. Ask about assessment, medication, administration, monitoring, therapy and maintenance charges separately. We do not assume a statewide price.
Spravato is FDA-approved esketamine, not the same as ketamine infusions. Coverage is not guaranteed. Check eligibility, prior authorization, network status, drug and visit charges, deductibles and copays with your insurer and clinic.
Spravato requires a certified healthcare setting and monitoring for at least two hours. Arrange transport home; do not drive until the next day after restful sleep. For other ketamine treatments, follow your clinician's instructions. Follow-up and maintenance depend on response and tolerability.
Ask who manages your medications, how your usual clinician will receive updates, and whom to contact between visits. Neither a shortage designation nor local depression statistics show that ketamine is appropriate or effective for you. Consult a licensed physician.
Use these questions when you call or book a consultation with any Littleton provider.
Ask whether a physician, psychiatrist or anesthesiologist oversees each session and who you can reach afterward.
A good clinic reviews your history, medications, blood pressure and past treatments before recommending ketamine.
Look for continuous vital-sign monitoring and a calm, private recovery space.
IV infusions, Spravato® nasal spray, IM or sublingual options suit different goals and budgets.
Ask how the clinic coordinates with your therapist or offers integration support between sessions.
Request a written estimate for the first series and any maintenance sessions before you start.
| Clinic | Google rating | Reviews | Phone |
|---|---|---|---|
| Balanced Mental Wellness - Psychiatry & KetamineLittleton | 4.8 | 263 | (303) 481-3489 |
| Ballen Medical & Wellness - Ketamine Therapy in DenverCentennial | 4.7 | 116 | (720) 740-5877 |
| NeuConnections Ketamine & Wellness ClinicHighlands Ranch | 5 | 90 | (303) 835-2073 |
| Rocky Mountain Mind and Body - integrative psychiatric practice and Ketamine Infusion TherapyEnglewood | 4.6 | 70 | (720) 729-4357 |
| Vitalitas Denver Ketamine Infusion CenterLittleton | 4.7 | 42 | (720) 724-8075 |
| Summit Ketamine InnovationsDenver | 4.5 | 22 | (720) 750-5818 |
| Sage Rose Health- Ketamine Therapy in Centennial, COCentennial | 5 | 1 | (720) 613-5734 |
| Ketamine Treatment DenverDenver | — | — | — |
Ratings come from public Google reviews and change over time. Listing order is not a medical recommendation.
Many patients travel a short distance for a clinic that fits their needs. Explore ketamine care in these nearby communities.
Browsing a wider area? See every clinic in Arapahoe County
Conditions Ketamine treats, county-wide options and guides written for Colorado patients.